Gentlemen, you should know better than to not consult me to answer your questions.
The worst college football game ever is widely considered to be the 1916 Georgia Tech vs. Cumberland College game, which ended with a record-setting 222–0 score. Cumberland had disbanded its football program but was still obligated to play, leading to a completely lopsided matchup.
Another contender for the "worst" is the 1978 Illinois vs. Northwestern 0–0 tie, which was famously uneventful and resulted in 77 punts between the two teams. Unfortunately, neither Illinois nor Northwestern disbanded after this game. It truly was a Golden Era of football ineptitude in the state of Illinois.
1916 Georgia Tech vs. Cumberland: The Ultimate Blowout
Score: 222–0
Context: Cumberland had folded its football program the previous season but was contractually obligated to play Georgia Tech.
Team: Cumberland's team was largely made up of players from the baseball team and other students.
Dominance: Georgia Tech led 126–0 at halftime, and the game was so uneven that the quarters were shortened from 15 minutes to 12.
1978 Illinois vs. Northwestern: The "Pointless Game"
Score: 0–0
Context: Both teams were struggling, with the combined record between them for the season being just one win.
Gameplay: The game was dominated by punts, setting a single-game record with 77 punts between the two teams. Neither team was able to muster a single score.
Nickname: The game became known as the "Pointless Game" or the "Toilet Bowl".
Other contenders
2015 Wake Forest vs. Boston College: This game ended with a score of 3–0 in favor of Wake Forest, and was notable for its offensive ineptitude from both sides.
2018 LSU vs. Texas A&M: While not a blowout, this seven-overtime game is often cited as a chaotic and unusual game due to the combined score of 146 points, which led to rule changes intended to prevent such an outcome in the future.